Genomics England

RAF1

Raf-1 proto-oncogene, serine/threonine kinase

Panel	Mode of inheritance	Details
Filter panels9 panels
Green in Adult solid tumours cancer susceptibility Signed-off version 2.2	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes LEOPARD syndrome 2 611554, Noonan syndrome 5 611553
Green in Childhood solid tumours R-numbers: R359 Signed-off version 4.0	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes LEOPARD syndrome 2 611554, Noonan syndrome 5 611553
Green in DDG2P Component of the following Super Panels: - Paediatric disorders Signed-off version 4.3	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes NOONAN SYNDROME 5 611553
Green in Fetal anomalies R-numbers: R21, R412 Signed-off version 4.0	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes NOONAN SYNDROME 5
Green in Intellectual disability Component of the following Super Panels: - Childhood onset leukodystrophy - Hypotonic infant - Paediatric disorders R-numbers: R29 Signed-off version 6.13	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes Noonan syndrome 5, 611553LEOPARD syndrome 2, 611554, NOONAN SYNDROME 5
Green in Monogenic short stature R-numbers: R453 Signed-off version 1.1	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes LEOPARD syndrome 2, OMIM:611554, Noonan syndrome 5, OMIM:611553
Green in Paediatric or syndromic cardiomyopathy Component of the following Super Panels: - Unexplained death in infancy and sudden unexplained death in childhood R-numbers: R135 Signed-off version 4.3	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes Noonan syndrome 5, Noonan syndrome, Noonan syndrome 5 611553, LEOPARD syndrome 2 611554, syndromic HCM, LEOPARD syndrome, LEOPARD syndrome 2
Green in Pigmentary skin disorders R-numbers: R236 Signed-off version 3.0	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes NS5, Noonan syndrome with lentigines (LEOPARD), LEOPARD SYNDROME 2, Noonan syndrome, LPRD2, NOONAN SYNDROME 5
Green in Primary lymphoedema R-numbers: R136 Signed-off version 3.0	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes Noonan syndrome 5 611553, LEOPARD syndrome 2 611554