Genomics England

LZTR1

leucine zipper like transcription regulator 1

Panel	Mode of inheritance	Details
Filter panels8 panels
Green in DDG2P Component of the following Super Panels: - Paediatric disorders Signed-off version 4.3	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Phenotypes Noonan syndrome
Green in Familial tumours of the nervous system R-numbers: R221 Signed-off version 2.0	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes
Green in Fetal anomalies R-numbers: R21, R412 Signed-off version 4.0	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Phenotypes Fetal hydrops, Noonan syndrome 10, 616564
Green in Intellectual disability Component of the following Super Panels: - Childhood onset leukodystrophy - Hypotonic infant - Paediatric disorders R-numbers: R29 Signed-off version 6.13	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Phenotypes Noonan syndrome 10, Prenatal hydrops, increased nuchal translucency, cardiac findings
Green in Monogenic short stature R-numbers: R453 Signed-off version 1.1	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Phenotypes Noonan syndrome 10, OMIM:616564 (AD), Noonan syndrome 2, OMIM:605275 (AR)
Green in Paediatric or syndromic cardiomyopathy Component of the following Super Panels: - Unexplained death in infancy and sudden unexplained death in childhood R-numbers: R135 Signed-off version 4.3	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Phenotypes Schwannomatosis-2, susceptibility to 615670, Noonan syndrome 10 616564
Green in Pigmentary skin disorders R-numbers: R236 Signed-off version 3.0	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Phenotypes NOONAN SYNDROME 10, NS2, NS10, NOONAN SYNDROME 2, Schwannomatosis-2, susceptibility to 615670, Noonan syndrome 10 616564
Green in Primary lymphoedema R-numbers: R136 Signed-off version 3.0	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Phenotypes Schwannomatosis-2, susceptibility to 615670, Noonan syndrome 10 616564