Genomics England

KRAS

KRAS proto-oncogene, GTPase

OMIM: 190070

Panel	Mode of inheritance	Details
Filter panels12 panels
Green in Adult solid tumours cancer susceptibility Signed-off version 2.2	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes Noonan syndrome 3 609942, Cardiofaciocutaneous syndrome 2 615278
Green in Childhood solid tumours R-numbers: R359 Signed-off version 4.0	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes Noonan syndrome 3 609942, Cardiofaciocutaneous syndrome 2 615278
Green in DDG2P Component of the following Super Panels: - Paediatric disorders Signed-off version 4.3	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes CARDIOFACIOCUTANEOUS SYNDROME 115150, NOONAN SYNDROME TYPE 3 609942
Green in Early onset or syndromic epilepsy Component of the following Super Panels: - Paediatric disorders - Unexplained death in infancy and sudden unexplained death in childhood R-numbers: R59 Signed-off version 5.10	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes Cardiofaciocutaneous syndrome 2, 615278
Green in Fetal anomalies R-numbers: R21, R412 Signed-off version 4.0	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes NOONAN SYNDROME TYPE 3, CARDIOFACIOCUTANEOUS SYNDROME
Green in Intellectual disability Component of the following Super Panels: - Childhood onset leukodystrophy - Hypotonic infant - Paediatric disorders R-numbers: R29 Signed-off version 6.13	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes Lung cancer, somatic, 211980Bladder cancer, somatic, 109800Pancreatic carcinoma, somatic, 260350Gastric cancer, somatic, 137215Leukemia, acute myelogenousNoonan syndrome 3, 609942Cardiofaciocutaneous syndrome 2, 615278Breast cancer, somatic, 114480SFM syndrome, somatic mosaic, 163200, CARDIOFACIOCUTANEOUS SYNDROME (CFC SYNDROME)
Green in Monogenic short stature R-numbers: R453 Signed-off version 1.1	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes Cardiofaciocutaneous syndrome 2, OMIM:615278, Noonan syndrome 3, OMIM:609942
Green in Mosaic skin disorders - deep sequencing R-numbers: R327 Signed-off version 2.0	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes Schimmelpenning syndrome, Epidermal naevi
Green in Paediatric or syndromic cardiomyopathy Component of the following Super Panels: - Unexplained death in infancy and sudden unexplained death in childhood R-numbers: R135 Signed-off version 4.3	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes Noonan syndrome 3, Noonan syndrome, CFC syndrome, Cardiofaciocutaneous syndrome 2 615278, Noonan syndrome 3 609942, Cardiofaciocutaneous syndrome 2, Cardiofaciocutaneous Syndrome, Cardio-Facio-Cutaneous syndrome
Green in Pigmentary skin disorders R-numbers: R236 Signed-off version 3.0	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes NOONAN SYNDROME 3, CARDIOFACIOCUTANEOUS SYNDROME 2, NOONAN SYNDROME 3, 609942, CFC2
Green in Primary lymphoedema R-numbers: R136 Signed-off version 3.0	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes Noonan syndrome 3 609942, Cardiofaciocutaneous syndrome 2 615278
Green in Rare syndromic craniosynostosis or isolated multisuture synostosis R-numbers: R100 Signed-off version 5.0	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes cardiofaciocutaneous syndrome type 2 615278, Noonan syndrome type 3 609942, 615278, 609942